Formulation of Regesta Tab
Itopride
Regesta (Itopride’s) primary mechanism of action involves its ability to regulate
gastrointestinal motility by acting on specific receptors in the digestive
system. It is a mixed agonist of dopamine type-2 (D2) and antagonist of
serotonin type-4 (5-HT4) receptors. By stimulating D2 receptors, itopride
inhibits the release of acetylcholine, which reduces gastrointestinal motility.
In contrast, its blockade of 5-HT4 receptors enhances gastrointestinal motility
by increasing acetylcholine release. This dual action helps regulate the
contractions of the stomach and intestines, improving gastric emptying and
reducing symptoms associated with gastrointestinal disorders.
Regasta is an acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting.
Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).
Regasta is also used to associated treatment for these conditions:
Abdominal Pain, Dyspepsia, Functional Dyspepsia, Gastroenteritis, Loss of Appetite, Nausea, Nausea and vomiting, Vomiting, Abdominal bloating, Pyrosis, Stomach discomfort
How Regesta work
Regasta has anticholinesterase (AchE) activity as well as dopamine D2 receptor antagonistic activity. It is well established that M3 receptors exist on the smooth muscle layer throughout the gut and acetylcholine (ACh) released from enteric nerve endings stimulates the contraction of smooth muscle through M3 receptors. The enzyme AChE hydrolyses the released ACh, inactivates it and thus inhibits the gastric motility leading to various digestive disorders. Besides ACh, dopamine is present in significant amounts in the gastrointestinal tract and has several inhibitory effects on gastrointestinal motility, including reduction of lower esophageal sphincter and intragastric pressure. These effects appear to result from suppression of ACh release from the myenteric motor neurons and are mediated by the D2 subtype of dopamine receptors. Regasta, by virtue of its dopamine D2 receptor antagonism, removes the inhibitory effects on Ach release.
Every medicine with active ingredients has side-effects. However, these side effects are very rare. Most of the individuals don’t face the side effects.
- Headache
- Allergic reaction
- Diarrhoea
- Abdominal pain
- Back and chest pain
- Constipation
Retest warnings include
- Be careful while using Regasta 50 mg Tablet without the doctor’s consent.
- If you have allergy problems, then inform your doctor.
- Share the list of all products (including allopathic and herbal) with your doctor.
- Use Regasta 50 mg Tablet as long as your doctor prescribed it.
- Do not change the dosage of Regasta 50 mg Tablet without the approval of the pharmacist or your doctor.
Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:
- For the treatment of gastrointestinal disorders such as nausea, vomiting, and diarrhea, the standard dosage is 50mg three times a day.
- For the treatment of gastrointestinal symptoms resulting from chemotherapy or radiation therapy, such as nausea, vomiting, and diarrhea, the recommended dosage is 50mg four times a day.
- Itopride Hydrochloride 50mg may also be used to treat other conditions, such as gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and gastroparesis. It’s crucial to follow your doctor’s instructions regarding dosage for these conditions, as it may vary.
- It’s worth noting that dosage instructions may vary from person to person, depending on the severity of their condition. To ensure the safest and most effective treatment, it’s recommended to consult a medical professional or a pharmacist before taking Itopride Hydrochloride 50mg.
Drug interaction
Following are the drug interactions for Itopride 50 mg Tablet:
- Itopride may interact with other dopamine antagonists, such as metoclopramide, leading to increased risk of extrapyramidal symptoms.
- Concomitant use with anticholinergic drugs can reduce the effectiveness of Itopride.
- Itopride can increase the absorption of certain medications, including antibiotics like erythromycin and antifungals like ketoconazole.
- The absorption of Itopride may be reduced when taken with proton pump inhibitors (PPIs) like omeprazole.
- Caution is advised when using Itopride with drugs that prolong QT interval, as it may increase the risk of cardiac arrhythmias.
- Itopride may increase the effects of anticoagulants, such as warfarin, requiring close monitoring of coagulation parameters.
- Interactions with other prokinetic agents like domperidone may increase the risk of adverse effects.
About Regesta Tab
Regasta Tablet is used to treat Gastroesophageal Reflux Disease. It helps reduce the sensation of bloating, nausea, vomiting, anorexia, heartburn, and chronic disorder.
Storage
Itopride 50mg Tablets should be stored in a secure and dry location, ideally in a medicine cabinet, at room temperature, which is typically between 20-25°C (68-77°F). Protect the tablets from light and moisture by keeping them in their original packaging, ensuring the container is tightly sealed. It’s crucial not to store them in the bathroom due to its humidity. Always check the expiry date before taking any medication, and if the tablets have passed their expiration, do not use them and dispose of them carefully. To safely dispose of Itopride tablets, do not flush them or throw them into the trash; instead, consult your pharmacist or a healthcare professional for guidance on proper disposal methods in your area, ensuring they are kept out of the reach of children and pets.